Plasma Cell Neoplasm Mimicking Metastatic Bone Disease in a Breast Cancer Survivor: A Case Report Highlighting the Role of Serum Protein Electrophoresis.

Arshiya Anjum, Sanjay Bagade, Sanath Kandem

Abstract readCase Reports

In one paragraph

Article in EJIFCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Arshiya AnjumBasavatarakam Indo-American Cancer Hospital and Research Institute, Department of clinical Biochemistry, Telangana, India.

Sanjay BagadeBasavatarakam Indo-American Cancer Hospital and Research Institute, Department of clinical Biochemistry, Telangana, India.

Sanath KandemBasavatarakam Indo-American Cancer Hospital and Research Institute, Department of Medical Oncology, Telangana, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer, a prevalent solid tumor, is the most common cancer among women worldwide. Hematological malignancies, such as acute myeloid leukemia, myelodysplastic syndrome, and acute lymphoblastic leukemia, are more frequent in breast cancer survivors, while plasma cell neoplasms are less common. We report the case of a 44-year-old woman with breast cancer who underwent neoadjuvant chemotherapy and surgery, presenting one year later with bone lesions and anemia. Initially suspected to be metastatic bone disease, the findings of elevated serum total protein and globulins prompted serum protein electrophoresis, which revealed a distinct M band in the gamma region, suggesting a plasma cell neoplasm. Further evaluation confirmed this diagnosis, and treatment was initiated. This case underscores the importance of considering elevated total protein, globulins, and an altered albumin-to-globulin ratio as primary bone marrow disorders, such as plasma cell neoplasms, in breast cancer patients with bone lesions.

Indexed as

Albumin-to-globulin ratiobone lesionsbreast cancerplasma cell neoplasmserum protein electrophoresis

Identifiers

PMID42006490

PMCPMC13088510

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