Evidence map›Paper›PMID 42006396›Full record

ArticleInternational journal of endocrinology2026

Obstructive Sleep Apnea and Female Reproductive Endocrine Diseases: A Mendelian Randomization and Mediation Analysis.

Zhe Wang, Jie Qin, Jia Wang, Ze Chen, Ziyu Qiao, Ming Yan, Dahai Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhe WangDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0009-0004-2098-9837
Jie QinDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0009-0000-1445-1724
Jia WangDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0009-0003-1013-0044
Ze ChenDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0000-0003-0421-1537
Ziyu QiaoDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0009-0008-2783-0254
Ming YanDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0009-0005-2783-6443
Dahai WuDepartment of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, 110016, Liaoning, China, syjqzyy.com.ORCID https://orcid.org/0000-0003-0649-0656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate the potential causal association between obstructive sleep apnea (OSA) and the risk of female reproductive endocrine diseases (REDs), including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI) using Mendelian randomization (MR) analysis. Methods: Genome-wide association study (GWAS) summary statistics were obtained from the FinnGen consortium, GWAS catalog, UK Biobank, and GIANT consortium, with a focus on individuals of European ancestry. Single-nucleotide polymorphisms (SNPs) correlated with OSA were investigated in relation to REDs (PCOS, EMs, and FI) using the inverse-variance weighted (IVW) method. Sensitivity analyses were used to test the consistency of the results. Furthermore, a two-step MR was performed to quantify the proportion of the effect of body mass index (BMI)-mediated OSA on REDs. Results: Our primary MR analysis revealed that genetically predicted OSA was positively linked to increased PCOS (odds ratio [OR] 1.341, 95% confidence interval [CI] 1.014-1.774, Conclusion: This study suggested that early detection and management of OSA in women may be a new strategy to improve PCOS in the future. Meanwhile, it also emphasized the importance of adjusting BMI as a therapeutic strategy to mitigate the effects of OSA on PCOS.

Indexed as

body mass indexendometriosisfemale infertilityMendelian randomizationobstructive sleep apneapolycystic ovary syndrome

Identifiers

PMID42006396
PMCPMC13087510

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.