ArticleiScience2026
Mapping burdens and inequalities of polycystic ovary syndrome in young females across 953 locations 1990-2040 with deep learning forecasts.
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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Adaptation and exploratory factor analysis of a PCOS-specific HRQoL questionnaire in a South Indian population.BMC women's health · 2026Article
- Subnational inequalities and preventable gaps in drowning premature mortality and non-fatal health loss among population younger than 20 years.Frontiers in public health · 2026Article
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Authors and funding
60 authors.
Yaling WuDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wenxiang CaiDepartment of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China.
Mao ChenDepartment of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Susu LuoThe Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China.
Robert J NormanRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Mahnaz Bahri KhomamiCentre for Research Excellence in Women's Health in Reproductive Life, Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC 3004, Australia.
Lisa MoranCentre for Research Excellence in Women's Health in Reproductive Life, Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC 3004, Australia.
Heping ZhangDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT 06520, USA.
Suhaniya N S SamarasingheDepartment of Endocrinology and Diabetes, Imperial College Healthcare NHS Trust, London SW7 2AZ, UK.
Salman RawafWHO Collaborating Centre for Public Health Education and Training, Department of Primary Care and Public Health, School of Public Health, Faculty of Medicine, Imperial College London, London W12 0BZ, UK.
Davd A EhrmannSection of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL 60637, USA.
Liming PanSchool of Cyber Science and Technology, University of Science and Technology of China, Hefei 230026, China.
Kexin DingDepartment of Computer Science, Rutgers University, New Brunswick, NJ 08901, USA.
Shuxian MaDigital Services Section, Information Management Branch, United Nations Office for the Coordination of Humanitarian Affairs, The Hague, the Netherlands.
Lili ZhengGlobal Traditional Medicine Centre, World Health Organisation, Geneva, Switzerland.
Xian ShaoDivision of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
You ZuoDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Baozhen HuangDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, China.
Fei LiGreater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou 511400, China.
Mingyang XueSchool of Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Tongrui ShangGuangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Guangyao CaiDepartment of Gynaecologic Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Centre for Cancer, Sun Yat-Sen University Cancer Centre, Guangzhou 510006, China.
Yuanyuan ChenState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Ying WangState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Yutong LuNational Supercomputer Center in Guangzhou, Sun Yat-sen University, Guangzhou 510006, China.
Dong WangNational Supercomputer Center in Guangzhou, Sun Yat-sen University, Guangzhou 510006, China.
Yuanyuan WanDepartment of Supercomputing Application Promotion, National Supercomputer Center in Guangzhou, Sun Yat-sen University, Guangzhou 510006, China.
Ningning WuDepartment of HPC Application, National Supercomputer Center in Guangzhou, Sun Yat-sen University, Guangzhou 510006, China.
Ciqing LinSchool of Computing and Information Systems, The University of Melbourne, Parkville, VIC 3052, Australia.
Wei PanFaculty of Social Sciences, Hong Kong Baptist University, Hong Kong, China.
Rui ZhangDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Tingting YaoDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Yiming XiongCollege of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.
Kai ChenGuangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Breast Tumor Center, Artifical Intelligence Lab, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Jianli ZhaoClinical Research Design Division, Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Breast Tumor Center, Clinical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Shunrong LiGuangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Liling ZhuGuangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Luyuan TanGuangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Yinduo ZengBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
You ZengDepartment of Women and Children Health Care, Guangzhou Baiyun District Maternal and Child Health Hospital, Guangzhou 510400, China.
Lukasz SzarpakDepartment of Clinical Research and Development, LUXMED Group, Warsaw, Poland.
Nadia M HamdyBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Claire Chenwen ZhongJC School of Public Health & Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 251780, China.
Fa YuanState Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Yihang ChuDepartment of Biomedical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 251780, China.
Xiao JiaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300000, China.
Peng WuState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China.
Linjiang WeiState Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China.
Yanfang YeClinical Research Design Division, Clinical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
João CondeToxOmics, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
Zimeng WuDepartment of Gynaecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jinjin ZhangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yamei TangDepartment of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Pengpeng YeThe George Institute for Global Health, University of New South Wales, Sydney, NSW 2000, Australia.
Dongzi YangDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Shixuan WangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Azeem MajeedDepartment of Primary Care and Public Health, Imperial College London, London W12 0BZ, UK.
Helena TeedeCentre for Research Excellence in Women's Health in Reproductive Life, Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC 3004, Australia.
Wenyi JinDepartment of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China.
Queran LinWHO Collaborating Centre for Public Health Education and Training, Department of Primary Care and Public Health, School of Public Health, Faculty of Medicine, Imperial College London, London W12 0BZ, UK.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder impacting the health of young female populations. Using harmonized estimates from 953 locations, we assessed temporal trends, geographic inequalities, and forecasts of PCOS among individuals aged 10-24 years from 1990 to 2040. Between 1990 and 2021, global prevalence and disability burden increased by more than 30%, with the highest burden observed among those aged 20-24 years. Substantial geographic heterogeneity was identified, with particularly high prevalence in Europe and East Asia. While high-income regions carried the greatest absolute burden, low- and middle-income regions showed the fastest growth, accompanied by widening socio-economic inequalities. Forecasting analyses suggest that PCOS burden in young populations will continue to rise through 2040. These findings characterize the evolving global landscape of PCOS, providing evidence to support targeted public health surveillance and prevention strategies for adolescent and young adult populations.
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health sciencesmedicinepublic healthreproductive medicine
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