Evidence map›Paper›PMID 42006353›Full record

ArticleiScience2026

Regulatory role of GLUT1 in lead-induced neurotoxicity and the neuroprotective effect of

Siyuan An, Yaming Ge, Yuye Liu, Zhe Sun, Meng Chen, Chengyu Chi, Zhihong Yin, Jing Liu, Jinglong Li, Lingli Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siyuan AnCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Yaming GeCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Yuye LiuCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Zhe SunCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Meng ChenCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Chengyu ChiCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Zhihong YinCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Jing LiuCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Jinglong LiSchool of Physical Education, Henan Institute of Science and Technology, Xinxiang, China.
Lingli ChenCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead (Pb) is a neurotoxic environmental pollutant that causes cognitive dysfunction and metabolic disturbances in the brain. Glucose transporter 1 (GLUT1) is essential for cerebral glucose metabolism, and altered expression may impair glucose uptake and utilization, synaptic plasticity, and cognitive performance. We found that acute Pb exposure impaired learning, memory, and anxiety-related behavior of mice. Fasting blood glucose concentrations increased in Pb-exposed mice, whereas GLUT1 expression in the brain was significantly decreased. GLUT1 overexpression alleviated Pb-induced synaptic structural and functional damage in Neuro-2a cells, whereas GLUT1 knockdown exacerbated these effects. Co-treatment with

Indexed as

Human metabolismNeurotoxicologyTherapeutics

Identifiers

PMID42006353
PMCPMC13084319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.