Evidence map›Paper›PMID 42006351›Full record

ArticleiScience2026

Structural evidence that RNA contributes to polymorphism of tau amyloid fibrils.

Romany Abskharon, Yi Xiao Jiang, Michael R Sawaya, Peng Ge, Jeffrey Zhang, David R Boyer, Joshua L Dolinsky, Justin Pi, Duilio Cascio, Feng Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Romany AbskharonDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Yi Xiao JiangDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Michael R SawayaDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Peng GeDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Jeffrey ZhangDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
David R BoyerDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Joshua L DolinskyDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Justin PiDepartment of Biological Chemistry, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Duilio CascioDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Feng GuoDepartment of Biological Chemistry, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
David S EisenbergDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.

Funding

Developing three-dimensional antisense oligonucleotide drugs against COVID-19R01AI163216 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GUO, FENG · 2021 to 2025
$2.3M
Structure-based antisense therapeutics targeting dystrophin exons 44 and 45 for Duchenne Muscular DystrophyR21HD115071 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GUO, FENG, MICELI, M CARRIE · 2024 to 2025
$433k
NIAID NIH HHS R01 AI163216NICHD NIH HHS R21 HD115071
6 · The paper itself

Abstract

RNA colocalizes with tau deposits in Alzheimer's disease (AD) and drives tau aggregation

Indexed as

biochemistryexperimental systems for structural biologystructural biology

Identifiers

PMID42006351
PMCPMC13091454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.