Evidence map›Paper›PMID 42006344›Full record

ArticleiScience2026

STARR-CRAAVT: A platform to identify cell type-specific regulatory elements for next-generation gene therapy.

Robert Becker, Priyanka Choudhury, Martin Oti, Youssef Fouani, Benjamin Strobel, Stephanie Ketterer, Simon Rumpel, John Park, Sebastian Kreuz, Udo Maier and 2 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Robert BeckerEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Priyanka ChoudhuryEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Martin OtiComputational Biology Eye Health & Emerging Areas, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Youssef FouaniEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Benjamin StrobelGlobal Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Stephanie KettererEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Simon RumpelInstitute of Physiology, FTN, University Medical Centre, Johannes Gutenberg University, 55131 Mainz, Germany.
John ParkCardio-Renal-Metabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Sebastian KreuzEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Udo MaierEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Stefan MichelfelderEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Christian SchönEye Health & Research Beyond Borders, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Designing enhancer-promoter combinations that enable potent and precise transgene expression is a promising strategy for advancing gene therapy mediated by adeno-associated virus (AAV). We introduce STARR-CRAAVT (self-transcribing active regulatory region sequencing of captured libraries for rAAV gene therapy), a STARR-Seq-based platform using

Indexed as

bioinformaticsbiological sciencescellular therapyhealth sciences

Identifiers

PMID42006344
PMCPMC13091475

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.