Evidence map›Paper›PMID 42006321›Full record

ArticleiScience2026

CryAB-driven amyloidogenesis in

Ziwei Zhao, Hui-Ying Lim, Elena Cannone, Giulia Marchetto, Marco Schiavone, Gaetano Vattemi, Yungui Guo, Zong-Heng Wang, Brian Glancy, Erika R Geisbrecht

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziwei ZhaoDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
Hui-Ying LimDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Elena CannoneDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.
Giulia MarchettoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Marco SchiavoneDepartment of Molecular and Translational Medicine, Zebrafish Facility, University of Brescia, 25123 Brescia, Italy.
Gaetano VattemiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Yungui GuoDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
Zong-Heng WangNational Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD 20892, USA.
Brian GlancyNational Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, MD 20892, USA.
Erika R GeisbrechtDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the small heat shock protein α-crystallin B (CryAB) result in cataracts, cardiomyopathies, and myofibrillar myopathies (MFMs), all of which are marked by protein aggregation. To investigate pathological mechanisms, we expressed four human CryAB disease alleles in

Indexed as

Biological sciencesMolecular biologyNeuroscience

Identifiers

PMID42006321
PMCPMC13089057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.