Evidence map›Paper›PMID 42006320›Full record

ArticleiScience2026

Distinct phosphoinositide signatures orchestrate FcεRI versus MRGPRX2 mast cell secretion.

Sewar Omari-Manaa, Roselyn Aharonov, Stephen J Galli, Hydar Ali, Ronit Sagi-Eisenberg

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sewar Omari-ManaaDepartment of Cell, Developmental and Regenerative Biology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Roselyn AharonovDepartment of Cell, Developmental and Regenerative Biology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Stephen J GalliDepartments of Pathology and of Microbiology and Immunology, and Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA 94305-5176, USA.
Hydar AliDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ronit Sagi-EisenbergDepartment of Cell, Developmental and Regenerative Biology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphoinositides (PIs) regulate mast cell (MC) secretory granule (SG) biogenesis and exocytosis, yet their compartment-specific roles in receptor signaling and secretion remain unclear. Using a rapamycin-inducible dimerization system to recruit site-specific lipid phosphatases to either the plasma membrane or the SGs, we assessed the impact of spatially restricted PI depletion on secretion triggered by FcεRI activation, the MRGPRX2 ligand substance P (SP), or receptor-independent calcium/phorbol ester stimulation. Our data reveal distinct and shared PI requirements for coupling FcεRI and MRGPRX2 signaling to the exocytic machinery and uncover PI derivatives that act locally at the SGs to modulate granule release. Together, these findings show that individual PIs differentially orchestrate allergic and neurogenic secretion pathways and fine-tune SG exocytosis through site-specific functions.

Indexed as

BiochemistryCell biologyImmunologyMolecular biologySignal processing

Identifiers

PMID42006320
PMCPMC13090623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.