Evidence map›Paper›PMID 42006319›Full record

ArticleiScience2026

Molecular signatures of cell diversity modulated by long noncoding RNAs in the human fetal spinal cord.

Nan Miao, Trevor Lee, Liying Chen, Hegan Zhang, Jing Wang, Julianne Sun, Jason Sun, Yongqiang Sha, Shi-Ying Huang, Tao Sun

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nan MiaoCenter for Precision Medicine, Huaqiao University, Xiamen, Fujian 361021, China.
Trevor LeeDepartment of Cell and Developmental Biology, Cornell University Weill Medical College, New York, NY 10065, USA.
Liying ChenQuanZhou Women's and Children's Hospital, Quanzhou, Fujian 362000, China.
Hegan ZhangQuanZhou Women's and Children's Hospital, Quanzhou, Fujian 362000, China.
Jing WangSchool of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian 361021, China.
Julianne SunXiamen Institute of Technology Attached School, Xiamen, Fujian 361021, China.
Jason SunXiamen Institute of Technology Attached School, Xiamen, Fujian 361021, China.
Yongqiang ShaCenter for Precision Medicine, Huaqiao University, Xiamen, Fujian 361021, China.
Shi-Ying HuangCollege of Ocean Food and Biological Engineering, Jimei University, Xiamen, Fujian 361021, China.
Tao SunCenter for Precision Medicine, Huaqiao University, Xiamen, Fujian 361021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human spinal cord controls sophisticated sensory perception and motor response across its extensive length. However, the spatial and temporal regulation of the generation of various motor neurons (MNs) and glial cells remains obscure. Using single-cell RNA sequencing (scRNA-seq) and single-cell Stereo RNA sequencing (scStereo RNA-seq), we here investigated and annotated molecular signatures of three neural stem cell (NSC) lineages, MNs, astrocytes, and oligodendrocytes, in the human fetal spinal cord from gestational week 8 (GW8) to GW12. We also found that some long noncoding RNAs (lncRNAs) have overlapping or reciprocal expression patterns with their adjacent coding genes, which are enriched with the promoter, enhancer, and CCCTC-binding factor (CTCF) in the same cell cluster. Our study generated a rich spatial expression library of molecular diversity of lncRNAs and their adjacent genes in neurons and glia in the human fetal spinal cord.

Indexed as

developmental biologygenomicsneuroscience

Identifiers

PMID42006319
PMCPMC13090696

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.