Evidence map›Paper›PMID 42006293›Full record

ArticleiScience2026

The long-term impact of neonatal hypoxic-ischemic brain injury on neural dynamics in deep-layer retrosplenial cortex and hippocampus in mice.

Lida Du, Meng Yang, Hendrik W Steenland, Zhengwei Luo, Andrea Ovcjak, Ruiyan Hu, Shuzo Sugita, Kaori Takehara-Nishiuchi, Luka Milosevic, Zhong-Ping Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lida DuDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Meng YangDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Hendrik W SteenlandDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Zhengwei LuoDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Andrea OvcjakDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Ruiyan HuDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Shuzo SugitaDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Kaori Takehara-NishiuchiDepartment of Psychology, University of Toronto, Toronto, ON, Canada.
Luka MilosevicInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Zhong-Ping FengDepartment of Physiology, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal hypoxic-ischemia (HI) often results in hypoxic-ischemic encephalopathy (HIE), a major cause of neonatal mortality and long-term neurodevelopmental deficits. While motor and cognitive impairments are common, the underlying neuronal mechanisms remain poorly understood. Using a mouse model of neonatal HI, we examined long-term effects on neuronal activity in the retrosplenial cortex (RSC) and hippocampus through simultaneous electrophysiological recordings in freely moving adults. HI mice showed a significant reduction in neurons recorded per tetrode, and remaining pyramidal neurons in the ipsilateral hemisphere exhibited abnormal bursting, synchrony, and pathological spike-field coupling to theta-alpha oscillations. These neural abnormalities coincided with impaired motor learning performance across training sessions. Our findings reveal persistent disruptions in firing patterns and RSC-hippocampus communication, providing insight into long-term motor learning deficits at the single-neuron level, following neonatal HI brain injury.

Indexed as

behavioral neuroscienceneurosciencesensory neuroscience

Identifiers

PMID42006293
PMCPMC13091419

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.