Evidence map›Paper›PMID 42006287›Full record

ArticleiScience2026

Cross-sectional and longitudinal associations between circadian alignment and stroke in US adults.

Bolin Li, Xinxin Feng, Jian Li, Danqiong Wang, Tao Li, Kexin Yin, Li Ma, Lijuan Qu, Jian Wang, Yuan Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bolin LiDepartment of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610014, China.
Xinxin FengDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiao Tong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
Jian LiThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, No. 99 Longcheng Street, Taiyuan, Shanxi 030032, China.
Danqiong WangDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan, Taiyuan, China.
Tao LiDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan, Taiyuan, China.
Kexin YinSchool of Basic Medicine, University of South China, Hengyang, Hunan 421001, China.
Li MaIntensive Care Unit, Bazhong Central Hospital, Bazhong, Sichuan 636000, China.
Lijuan QuDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan, Taiyuan, China.
Jian WangDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan, Taiyuan, China.
Yuan ChenDepartments of Geriatrics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Tingting ZhengDepartment of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital Taiyuan, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythm disorders can cause metabolic disturbances and increase susceptibility to stroke. This study utilized circadian rhythm data from individuals aged 20 years and older in the NHANES (2011-2014) database. Cross-sectional and longitudinal analyses employed phase analysis (including the assessment of phase magnitude and phase acrophase) to explore associations between the light-dark cycle and the activity-rest cycle within circadian rhythms. The average follow-up duration was 83 months. Participants with the lowest phase magnitude (i.e., the least overlap between the light cycle and activity cycle) exhibited significantly increased risks of stroke, all-cause mortality, and cardiovascular mortality. Among those with low phase magnitude, women and older adults were more prone to stroke than men and younger adults, while men and older adults were more susceptible to cardiovascular mortality and all-cause mortality. These findings underscore the importance of quantitatively assessing circadian disruption and suggest that targeted interventions aimed at improving circadian alignment may play a role in mitigating stroke-related risk.

Indexed as

neurologypublic health

Identifiers

PMID42006287
PMCPMC13090959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.