Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells.

Henry A Paz, Ying Zhong, David K Williams, Kartik Shankar, Aline Andres, Umesh D Wankhade

Abstract read

In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henry A PazArkansas Children's Nutrition Center, Little Rock, AR, United States.

Ying ZhongDepartment of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

David K WilliamsDepartment of Biostatistics, Colleges of Medicine and Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

Kartik ShankarDepartment of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Aurora, CO, United States.

Aline AndresArkansas Children's Nutrition Center, Little Rock, AR, United States.

Umesh D WankhadeArkansas Children's Research Institute, Little Rock, AR, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess the adipogenic potential and mitochondrial bioenergetics of umbilical cord mesenchymal stem cells (UC-MSCs) derived from infants born to mothers with divergent body mass index and to evaluate the associations between maternal BMI and adipogenic gene expression. Methods: UC-MSCs were isolated and cultured from infants born to mothers with normal weight (22.2 ± 0.3 kg/m Results: OW/OB-MSCs exhibited an impaired adipogenic phenotype, characterized by reduced protein levels of Conclusions: Prenatal exposure to maternal obesity may disrupt programming of adipose precursors in offspring, impairing their adipogenic capacity and mitochondrial function, and potentially predisposing them to metabolically compromised adipose tissue later in life.

Indexed as

AdipogenesisMesenchymal Stem CellsMitochondriaObesityPregnancy in ObesityAdultBody Mass IndexCCAAT-Enhancer-Binding ProteinsCell DifferentiationCell RespirationCells, CulturedFemaleHumansInfant, NewbornPregnancyUmbilical CordCCAAT-Enhancer-Binding Proteinsadipogenic differentiationdevelopmental programmingmaternal obesitymitochondrial respirationumbilical cord mesenchymal stem cells

Identifiers

PMID42006275

DOI10.3389/fendo.2026.1786389

PMCPMC13082967

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.