Evidence map›Paper›PMID 42006254›Full record

ArticleACS bio & med chem Au2026

Pyrazolylpyrimidinamines Decorated via Petasis Reaction as Small-Molecule Activators of the RNA-Degrading Ribonuclease IRE1α.

Amrutha K Avathan Veettil, Yang Liu, Leon Wagner, Oguz Hastürk, Nguyen Song Thu Huynh, Giorgia Mancino, Maria Beerbaum, Peng Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS bio & med chem Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amrutha K Avathan VeettilChemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
Yang LiuChemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.ORCID https://orcid.org/0000-0002-5071-3928
Leon WagnerChemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
Oguz HastürkChemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
Nguyen Song Thu HuynhChemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
Giorgia MancinoDepartment of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Maria BeerbaumDepartment of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.ORCID https://orcid.org/0009-0001-1655-0715
Peng WuChemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.ORCID https://orcid.org/0000-0002-0186-1086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multicomponent Petasis boron-Mannich reaction (PR) enables the generation of functionalized amines that are of biological interest. Here, we demonstrated that a series of pyrazolylpyrimidinamines decorated via PR are new small-molecule activators of the dual kinase and ribonuclease RNA-degrading protein inositol-requiring enzyme 1α (IRE1α), which is an essential effector in the unfolded protein response associated with many human diseases. Compound SH4 was identified via a FRET assay and showed potent activity in activating the IRE1α ribonuclease (RNase) activity, inducing increased

Indexed as

Petasis reactionpyrimidinamineribonucleaseRNA degradationsmall-molecule activator

Identifiers

PMID42006254
PMCPMC13087800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.