Evidence map›Paper›PMID 42006252›Full record

ArticleACS bio & med chem Au2026

Ligand-Induced Opening of a Cryptic Pocket in METTL14.

Ivan Corbeski, Rajiv Kumar Bedi, Christian M Matter, Fiona Stamm, Elena Bochenkova, Marcin Herok, Michael J Hartshorn, Amedeo Caflisch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS bio & med chem Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivan CorbeskiDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.ORCID https://orcid.org/0000-0002-5881-8425
Rajiv Kumar BediDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.ORCID https://orcid.org/0000-0002-8193-9006
Christian M MatterDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.ORCID https://orcid.org/0009-0008-0924-6564
Fiona StammDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.
Elena BochenkovaDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.
Marcin HerokDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.
Michael J HartshornDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.
Amedeo CaflischDepartment of Biochemistry, University of Zurich, Zurich 8057, Switzerland.ORCID https://orcid.org/0000-0002-2317-6792

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the main human enzyme that deposits the most abundant internal mRNA modification, N

Indexed as

epitranscriptomicsexosite ligandsm6A-RNAmolecular dynamicsprotein crystallographyRNA-methyltransferase

Identifiers

PMID42006252
PMCPMC13087807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.