Evidence map›Paper›PMID 42006200›Full record

ArticleKidney international reports2026

Impact of Cold Ischemia Time on Allograft Survival and Policy.

Sai Rithin Punjala, April Logan, Ashley J Limkemann, Navdeep Singh, Musab Alebrahim, Timothy M Pawlik, William K Washburn, Austin D Schenk

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In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sai Rithin PunjalaDivision of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
April LoganDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Ashley J LimkemannDivision of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Navdeep SinghDivision of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Musab AlebrahimDivision of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Timothy M PawlikDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
William K WashburnDivision of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Austin D SchenkDivision of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Changes in national allocation policy and regulatory practices have led to increases in cold ischemia time (CIT) and out-of-sequence allocation (AOOS) or expedited placement (EP) of deceased donor kidney transplants in the United States. The aims of this study were to gauge the clinical relevance of the increased CIT that accompanied kidney allocation system (KAS) 250 NM (KAS250), and to measure CIT for AOOS or EP kidneys. Methods: The United Network for Organ Sharing (UNOS) data from 2007 to 2023 were analyzed across pre-KAS, KAS, and KAS250 eras. The impact of CIT on kidney graft survival and the CIT of kidneys undergoing AOOS or EP during these eras was assessed. Results: Median CIT increased from 16 hours to 19.6 hours, and the incidence of AOOS or EP increased from 0.5% to 13%. Transplants with CIT of 32 to 36 hours had a 10% increase in overall graft loss compared with CIT of 16 to 20 hours ( Conclusion: Current allocation practices do not prioritize CIT. Extended CIT is associated with inferior long-term graft survival. AOOS or EP is designed to prevent discards but does not currently target high KDPI kidneys. Our data provide a framework to assess the relative importance of CIT in allocation policy.

Indexed as

allocation out-of-sequencecold ischemia timeexpedited placementKDPIkidney allocation system 250 NMkidney transplantation

Identifiers

PMID42006200
PMCPMC13088964

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.