Evidence map›Paper›PMID 42006143›Full record

ArticleFrontiers in cellular and infection microbiology2026

Integrated transcriptomic analysis reveals miRNA-hub mRNA-TF interactions and key regulatory targets in

Baili Zheng, Xiaoyue Su, Yongchao Li, Qiang Fu, Xuelian Ma, Bao Zhou, Bing Peng, Rulong Chen, Yingyu Liu

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baili Zheng *College of Veterinary Medicine, Xinjiang Key Laboratory of Herbivore Drug Research and Creation, Xinjiang Agricultural University, Urumqi, China.
Xiaoyue Su *Bayinguoleng Vocational and Technical College, Korla, Bayinguoleng, China.
Yongchao LiCollege of Veterinary Medicine, Xinjiang Key Laboratory of Herbivore Drug Research and Creation, Xinjiang Agricultural University, Urumqi, China.
Qiang FuCollege of Veterinary Medicine, Xinjiang Key Laboratory of Herbivore Drug Research and Creation, Xinjiang Agricultural University, Urumqi, China.
Xuelian MaCollege of Veterinary Medicine, Xinjiang Key Laboratory of Herbivore Drug Research and Creation, Xinjiang Agricultural University, Urumqi, China.
Bao ZhouXinjiang Tianlai Agricultural and Animal Husbandry Group Co., Ltd., Bole, China.
Bing PengCollege of Veterinary Medicine, Xinjiang Key Laboratory of Herbivore Drug Research and Creation, Xinjiang Agricultural University, Urumqi, China.
Rulong ChenXinjiang Tianlai Agricultural and Animal Husbandry Group Co., Ltd., Bole, China.
Yingyu LiuCollege of Veterinary Medicine, Xinjiang Key Laboratory of Herbivore Drug Research and Creation, Xinjiang Agricultural University, Urumqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Shiga toxin-producing Methods: An Results: Infection of HIECs with STEC (10 Conclusion: STEC infection drastically reprograms the transcriptomic landscape of HIECs, triggering the dysregulation of inflammation and apoptosis-related pathways. This study is the first to delineate a comprehensive miRNA-mRNA-TF regulatory network for STEC infection, highlighting miR-3121-3p, miR-219b-5p, and miR-543 as key molecular mediators. These findings provide novel insights into the molecular pathogenesis of STEC and lay a crucial foundation for exploring potential regulatory and host-directed therapeutic targets.

Indexed as

Epithelial CellsEscherichia coli InfectionsIntestinal MucosaMicroRNAsRNA, MessengerShiga-Toxigenic Escherichia coliTranscription FactorsApoptosisGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHemolytic-Uremic SyndromeHost-Pathogen InteractionsHumansProtein Interaction MapsTranscriptomeMicroRNAsRNA, MessengerTranscription Factorsgene regulatory networksmicroRNAregulatory targetRNA sequencingShiga toxin-producing Escherichia coli

Identifiers

PMID42006143
PMCPMC13083180

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.