Evidence map›Paper›PMID 42006142›Full record

ArticleFrontiers in cellular and infection microbiology2026

A conserved KL2-capsule-related phage-resistant mechanism in carbapenem-resistant

Yong Shao, Zhu Gao, Hongyang You, Shaokun Zhang, Jiaqi Zeng, Jiawei Zhao, Chenyan Yuan, Fengqin Miao, Yuqing Shen, Ying Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Quorum sensing geneFrontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yong ShaoSchool of Life Science and Technology, Southeast University, Nanjing, China.
Zhu GaoSchool of Life Science and Technology, Southeast University, Nanjing, China.
Hongyang YouSchool of Life Science and Technology, Southeast University, Nanjing, China.
Shaokun ZhangDepartment of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Jiaqi ZengDepartment of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Jiawei ZhaoDepartment of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Chenyan YuanDepartment of Clinical Laboratory, Zhongda Hospital, Southeast University, Nanjing, China.
Fengqin MiaoDepartment of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Yuqing ShenDepartment of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Ying ZhangDepartment of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Ling LiuJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Jianqiong ZhangSchool of Life Science and Technology, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: As the use of bacteriophages to combat drug-resistant bacteria increases, phage resistance, which may lead to infection recurrence, has gradually gained attention. The intricate mechanisms underlying phage resistance, which are crucial for improving the efficacy of phage therapy, have not yet been fully delineated. This research focuses on uncovering the mechanisms of phage resistance and formulating robust strategy to address infections caused by carbapenem-resistant Methods: A specific bacterium-phage pair (CRAB strain MRAB11 and lytic phage MRABP9) was employed. Phage-resistant strains were isolated and subjected to whole-genome sequencing, followed by comparative genomics analysis. A novel phage targeting phage-resistant strains, was screened and combined with MRABP9. The efficacy of the phage combination was validated in bacterial liquid growth and in mouse wound CRAB infection model. The antimicrobial spectra of phage MRABP9 and the phage combination were evaluated using multi-center clinical Results: All sequenced phage-MRABP9-resistant strains harbored mutations on KL2 locus under both Conclusions: The mechanism underlying the response of MRAB11 to phage MRABP9 invasion exhibits high consistency on KL2 locus and is surmountable by a well-designed dual-phage cocktail. This study offers valuable guidance for future experimental design of clinical phage therapy, and points out potential therapeutic phage candidates for treating CRAB infections.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsBacteriophagesCarbapenemsPhage TherapyAnimalsAnti-Bacterial AgentsDisease Models, AnimalHumansMiceMicrobial Sensitivity TestsMutationWhole Genome SequencingAnti-Bacterial AgentsCarbapenemsAcinetobacter baumanniibacterial infectionphage cocktailphage resistancephage therapy

Identifiers

PMID42006142
PMCPMC13083202

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.