Evidence map›Paper›PMID 42006042›Full record

ArticleAdvanced functional materials2026

Structurally Engineered Ferrous Metal-Organic Framework as a Chemodynamic Therapy Nanoagent for Concurrent Hydroxyl Radical and Singlet Oxygen Generation.

Chao Wang, Kongbrailatpam Shitaljit Sharma, Yoon Tae Goo, Vladislav Grigoriev, Constanze Raitmayr, Ana Paula Mesquita Souza, Manali Parag Phawde, Olena R Taratula, Oleh Taratula

Abstract read
In one paragraph

Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chao WangDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Kongbrailatpam Shitaljit SharmaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Yoon Tae GooDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Vladislav GrigorievDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Constanze RaitmayrDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Ana Paula Mesquita SouzaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Manali Parag PhawdeDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Olena R TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.
Oleh TaratulaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 SW Moody Avenue, Portland, Oregon, 97201, USA.

Funding

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer CachexiaR37CA234006 · NCI · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2019 to 2025
$3.2M
Intravascular Delivery of Nanoclusters for Treatment of Deep-Seated Cancers with Magnetic HyperthermiaR01CA237569 · NCI · OREGON STATE UNIVERSITY · PI TARATULA, OLEH · 2020 to 2024
$2.7M
Nanoparticle-mediated placental imaging and magnetic hyperthermia for management of ectopic pregnancyR01HD112007 · NICHD · OREGON STATE UNIVERSITY · PI Olena Taratula · 2023 to 2026
$2.4M
Development of magnetic hyperthermia for the systemic treatment of endometriosisR01HD101450 · NICHD · OREGON STATE UNIVERSITY · PI SLAYDEN, OV D, TARATULA, OLEH · 2021 to 2024
$2.4M
NCI NIH HHS R01 CA237569NCI NIH HHS R37 CA234006NICHD NIH HHS R01 HD101450NICHD NIH HHS R01 HD112007
6 · The paper itself

Abstract

Chemodynamic therapy (CDT) is an emerging cancer treatment that employs transition metal-based nanoagents to catalyze the conversion of elevated intracellular hydrogen peroxide in malignant cells into cytotoxic hydroxyl radicals (•OH) via Fenton-like reactions. Recent developments have also introduced CDT agents that generate singlet oxygen (

Indexed as

Chemodynamic therapy (CDT)Fenton reactionmetal-organic framework (MOF)reactive oxygen species (ROS)Russell mechanism

Identifiers

PMID42006042
PMCPMC13089975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.