ArticleEFSA journal. European Food Safety Authority2016
Guidance on the establishment of the residue definition for dietary risk assessment.
Article in EFSA journal. European Food Safety Authority, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Pesticide Residues in Vegetables: The Potential Risk Assessment of Endocrine and Reproductive Disruptors for Children and Adults.Foods (Basel, Switzerland) · 2026Article
- Article
- Scientific Opinion on the application of physiologically based kinetic (PBK) modelling for the quantitative in vitro to in vivo extrapolation (QIVIVE) of developmental neurotoxicity in vitro battery (DNT IVB) data for pesticide active substances.EFSA journal. European Food Safety Authority · 2025Article
- Guidance on the use of read-across for chemical safety assessment in food and feed.EFSA journal. European Food Safety Authority · 2025Article
- Article
- Bridging science and curriculum: preparing future leaders in computational toxicology.Frontiers in toxicology · 2025Review
- Re-evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives.EFSA journal. European Food Safety Authority · 2024Article
- Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products.Environmental health : a global access science source · 2024Review
- Assessment of fall-back MRLs for revoked CXLs previously implemented in the EU legislation and review of the JMPR evaluation of the toxicological data related to pyrasulfotole, pyraziflumid, spiropidion and tetraniliprole.EFSA journal. European Food Safety Authority · 2024Article
- Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics.Nature communications · 2023Article
- Guidance document on the impact of water treatment processes on residues of active substances or their metabolites in water abstracted for the production of drinking water.EFSA journal. European Food Safety Authority · 2023Article
- Metabolites in the regulatory risk assessment of pesticides in the EU.Frontiers in toxicology · 2023Review
- Retrospective cumulative dietary risk assessment of craniofacial alterations by residues of pesticides.EFSA journal. European Food Safety Authority · 2022Article
- Modification of the existing maximum residue level for apricots and setting of import tolerances for cyantraniliprole in various crops.EFSA journal. European Food Safety Authority · 2022Article
- Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on testing and interpretation of comparativeEFSA journal. European Food Safety Authority · 2021Article
- Article
- Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health.EFSA journal. European Food Safety Authority · 2021Article
- A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling.Regulatory toxicology and pharmacology : RTP · 2021Article
- The role of validation in establishing the scientific credibility of predictive toxicology approaches intended for regulatory application.Computational toxicology (Amsterdam, Netherlands) · 2021Review
- Cumulative dietary risk assessment of chronic acetylcholinesterase inhibition by residues of pesticides.EFSA journal. European Food Safety Authority · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EFSA has asked the Panel on Plant Protection Products and their Residues to prepare guidance on the establishment of the residue definition for dietary risk assessment. The residue definition for risk assessment is used by risk assessors to evaluate the potential risk of dietary intake of residues resulting from the application of a pesticide. This document guides the complex process of identifying the pertinent residue components that should be considered for dietary risk assessments of chemical active substances. Specifically, the document provides directions for determining the metabolites that require hazard identification and characterisation using scientific tools and methods ((quantitative) structure-activity relationship ((Q)SAR), read-across, threshold of toxicological concern (TTC)) and available data in combination, and for developing an appropriate testing strategy for these compounds. Further, for activities within the remit of the guidance document the terms 'potency' and 'toxicological burden' for consumers are defined and decision criteria established for the selection of the residue components that should be included in the residue definition for dietary risk assessment. In order to support the decision process it is recommended to make use of all information available, including mechanistic understanding, and to present detailed information on toxicity and exposure for every single metabolite and on the uncertainties connected to the proposed residue definition. The guidance document is complemented with three practical case studies demonstrating the applicability of the proposed decision scheme.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.