Evidence map›Paper›PMID 42006011›Full record

ArticleBioactive materials2026

A bioactive magnesium alloy scaffold integrated with BMSCs-Loaded 3D microspheres synergistically promotes femoral head osteonecrosis repair by improving the osteogenic-angiogenic microenvironment.

Minzheng Guo, Haojing Xu, Zijie Pei, Baochuang Qi, Chen Meng, Xusheng Chen, Huan Luo, Junxiao Ren, Zhihao Wang, Lin Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Minzheng GuoBeijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
Haojing XuState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, China.
Zijie PeiBeijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
Baochuang QiOrthopedic Trauma Center, Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Chinese Medicine, China.
Chen MengGraduate School, Kunming Medical University, Kunming, 650500, Yunnan, China.
Xusheng ChenGraduate School, Kunming Medical University, Kunming, 650500, Yunnan, China.
Huan LuoGraduate School, Kunming Medical University, Kunming, 650500, Yunnan, China.
Junxiao RenGraduate School, Kunming Medical University, Kunming, 650500, Yunnan, China.
Zhihao WangOrthopedic Trauma Center, Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Chinese Medicine, China.
Lin WangBeijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
Qingyun XueBeijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
Lei ShiBeijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
Yu RaoGraduate School, Kunming Medical University, Kunming, 650500, Yunnan, China.
Peng WenState Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Department of Mechanical Engineering, Tsinghua University, China.
Chuan LiDepartment of Orthopaedics, China-Japan Friendship Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteonecrosis of the Femoral Head (ONFH) is primarily characterized by impaired osteogenesis and insufficient vascularization, leading to progressive structural collapse and limb dysfunction. To develop a targeted strategy for regulating the bone-vascular microenvironment in hip preserving treatment, we integrated a three-dimensionally (3D) printed microporous magnesium alloy scaffold with bone marrow mesenchymal stem cells (BMSCs)-loaded 3D microspheres into a composite regenerative system. We then evaluated its therapeutic efficacy and investigated its underlying mechanisms. In vitro, the composite system demonstrated favorable biocompatibility and promoted osteogenic and angiogenic differentiation. In a steroid-induced rabbit model of femoral head necrosis, micro-CT and histological analysis confirmed the system's significant interventional effect. The magnesium alloy scaffold provided adequate mechanical support and released Mg

Indexed as

3D microspheresComposite scaffoldFemoral head necrosisMagnesium alloy

Identifiers

PMID42006011
PMCPMC13085025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.