Evidence map›Paper›PMID 42006006›Full record

ArticleBioactive materials2026

A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects.

Ying Yin, Yuting Cai, Pengrui Dang, Wenyi Zeng, Lu Wang, Xu Yan, Zhengtang Luo, Wenwen Liu, Yangzhi Zhu, Lili Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ying YinHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, China.
Yuting CaiDepartment of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, 94720, California, United States.
Pengrui DangThe VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, 110002, China.
Wenyi ZengHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, China.
Lu WangHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, China.
Xu YanThe VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, 110002, China.
Zhengtang LuoDepartment of Chemical and Biological Engineering, William Mong Institute of Nano Science and Technology, and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong, China.
Wenwen LiuDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.
Yangzhi ZhuTerasaki Institute for Biomedical Innovation, Los Angeles, CA 91367, United States.
Lili ChenHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, China.
Chenguang ZhangHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infected bone defects present a major clinical challenge, requiring precise sequential therapy that transitions from antibacterial activity to bone regeneration. Piezoelectric materials can transduce external stimulation into bioelectrical cues, providing a promising controllable handle to regulate antibacterial and osteogenic processes. However, conventional piezoelectric scaffolds often lack the capacity to distinctly separate these multifunctional roles, making it difficult to meet the therapeutic needs of different stages in the treatment of infected bone defects. Here, we develop a programmable NIR-responsive periosteum scaffold featuring a Janus bilayer architecture, in which a PDA-rich photothermal side and a non-photothermal piezoelectric side enable spatially separated antibacterial and osteogenic functions. This system integrates a thermoresponsive hydrogel with a piezoelectric polyvinylidene fluoride/barium titanate (PVDF/BT) electrospun membrane, achieving three switchable functional modes: continuous NIR irradiation for antibacterial therapy, intermittent irradiation for immunomodulation, and no irradiation for mechanical support and Ca

Indexed as

Infected bone regenerationNear-infrared stimulationPiezoelectric scaffoldsSequential therapyThermoresponsive hydrogels

Identifiers

PMID42006006
PMCPMC13085010

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.