Evidence map›Paper›PMID 42006001›Full record

ArticleBioactive materials2026

Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis.

Yu Xu, Wenpeng Xu, Wencan Zhang, Shangzhi Li, Dingxin Zhang, Xiangyu Lin, Qian Sun, Yanguo Wang, Peijie Hu, Haipeng Si

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu XuDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Wenpeng XuDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Wencan ZhangDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shangzhi LiDepartment of Orthopedics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Dingxin ZhangDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiangyu LinDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Qian SunDepartment of Medical Experimental Center, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Yanguo WangDepartment of Orthopedics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Peijie HuDepartment of Medical Experimental Center, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Haipeng SiDepartment of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoid-induced osteoporosis (GIOP) is a prevalent and serious side effect of long-term glucocorticoid therapy, characterized by elevated oxidative stress and profound suppression of bone formation. There is a lack of therapies that effectively target the underlying oxidative stress and impaired osteogenesis simultaneously. In this study, we aimed to identify novel therapeutic agents from a library of quinonoid compounds. Using a high-throughput screen with

Indexed as

Adenosine A2b receptorcAMP/PKA/CREB pathwayCD39/CD73/ADO axisDecylubiquinoneGlucocorticoid-induced osteoporosis

Identifiers

PMID42006001
PMCPMC13085024

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.