Evidence map›Paper›PMID 42005967›Full record

ArticleClinical parkinsonism & related disorders2026

Essential tremor-like phenotype in Fragile X carrier women.

Deborah A Hall, Danuta Loesch, Tyler Svymbersky, Elizabeth Berry-Kravis, Bichun Ouyang

Abstract read
In one paragraph

Article in Clinical parkinsonism & related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deborah A HallDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Danuta LoeschDepartment of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Bundoora, VIC, Australia.
Tyler SvymberskyDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Elizabeth Berry-KravisDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.
Bichun OuyangDepartment of Neurological Sciences, Rush University Medical Center, Chicago, USA.

Funding

Project 3- FXPOI: Mechanisms and ModifiersP50HD118707 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Loren Nelson, Peter K Todd · 2025 to 2026
$4.8M
NICHD NIH HHS P50 HD118707
6 · The paper itself

Abstract

Background: Tremor is a key feature of the neurodegenerative fragile X-associated tremor ataxia syndrome (FXTAS) and typically affects fragile X gene ( Objective: To determine if tremor occurs in Methods: Data from two cohorts of premutation carriers (n = 97) and controls (n = 22) were analyzed, and included FXTAS rating scale items such as handwriting, spiral drawing, and finger-to-nose maneuver as rated by a movement disorder neurologist who was blinded to gene status. Premutation carriers who met criteria for FXTAS were excluded. Descriptive, univariate and multivariate methods were used to analyze the differences between the groups. Results: FXTAS Rating Scale scores were higher in premutation carriers without FXTAS compared to controls (7 ± 5 vs. 4 ± 3, p = 0.002) and remained significantly higher after correcting for age (p = 0.003). Individual tremor items that were significantly worse included finger-to-nose and spiral drawing. Conclusions: Isolated hand tremor can be seen in

Indexed as

Fragile X premutationFXTASTremor

Identifiers

PMID42005967
PMCPMC13091058

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.