ArticleEClinicalMedicine2026
Nitrous oxide for late-life depression with inadequate antidepressant response: a randomised controlled trial.
Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
18 authors.
Funding
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Abstract
Background: Late-life depression with inadequate antidepressant response is a pressing clinical issue with limited proven therapies. Nitrous oxide (N Methods: We conducted a double-blind, randomised, placebo-controlled, single-dose trial (November 2021-December 2024) in three old-age psychiatry departments at French university hospitals. Eligible participants were aged 60-90 years with a current major depressive episode, a Montgomery-Åsberg Depression Rating Scale (MADRS) score >20 and documented non-response to ≥1 adequate antidepressant trial. Participants were randomly assigned (1:1) to a single 60-min inhalation of either 50% N Findings: Among the 60 participants enrolled in the study, those who received N Interpretation: While further studies are needed to confirm its long-term efficacy and safety, our findings suggest that N Funding: This study was supported by a grant from the French Ministry of Health and Prevention.
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