Evidence map›Paper›PMID 42005818›Full record

ArticleRegenerative biomaterials2026

An interfacial hydrogel compartment within a multicompartment tendon-to-bone scaffold influences cell behavior under cyclic tensile loading.

Kyle B Timmer, Megan L Killian, Brendan A C Harley

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyle B TimmerDepartment Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Megan L KillianDepartment of Orthopaedic Surgery, University of Michigan Ann Arbor, Ann Arbor, MI 48109, USA.
Brendan A C HarleyDepartment Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID https://orcid.org/0000-0001-5458-154X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injuries to spatially graded insertional tissues such as the tendon-to-bone enthesis in the rotator cuff present unique challenges for regenerative engineering. To address these, tissue engineering approaches are increasingly considering the use of biomaterials that display spatially graded properties to mimic aspects of the tendon, bone and connecting fibrocartilage enthesis zones. Mechanical loading introduces an additional opportunity to locally deliver disparate mechanical signals to cells across a biomaterial that contains spatial changes in composition, structure or mechanical properties. Here, we demonstrate the significance of

Indexed as

biomaterialcyclic tensile loadingmesenchymal stem cellsrotator cuff enthesis

Identifiers

PMID42005818
PMCPMC13091616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.