Evidence map›Paper›PMID 42005688›Full record

ArticleHealth science reports2026

Serum-Based miRNA Panel as Diagnostic Biomarkers for Hepatitis C Virus-Induced Hepatocellular Carcinoma: A Cross-Sectional Study.

Badr Alzahrani, Yasmeen Ishaq, Qaiser Farid Khan, Tawaf Ali Shah, Gamal A Shazly, Mohammed Bourhia, Aqsa Ikram

Abstract read
In one paragraph

Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Badr AlzahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences Jouf University Sakaka Saudi Arabia.
Yasmeen IshaqInstitute of Molecular Biology and Biotechnology (IMBB) University of Lahore (UOL) Lahore Pakistan.
Qaiser Farid KhanDepartment of Microbiology, Ikam ul Haq Institute of Industrial Biotechnology Government College University Lahore Pakistan.ORCID https://orcid.org/0000-0003-4433-0151
Tawaf Ali ShahCollege of Agriculture Engineering and Food Science Shandong University of Technology Zibo China.ORCID https://orcid.org/0000-0002-5030-4729
Gamal A ShazlyDepartment of Pharmaceutics, College of Pharmacy King Saud University Riyadh Saudi Arabia.
Mohammed BourhiaDepartment of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy Ibn Zohr University Laayoune Morocco.
Aqsa IkramInstitute of Molecular Biology and Biotechnology (IMBB) University of Lahore (UOL) Lahore Pakistan.ORCID https://orcid.org/0000-0001-7292-6134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Hepatocellular carcinoma (HCC) is responsible for more than 90% of primary hepatic cancer. Hepatitis C virus (HCV) infection is one of the contributing factors for HCC development. miRNAs are non-coding RNAs and are also involved in HCV replication. Expression variability of miRNA has also been reported in various cancers, including HCC. Methods: By using different bioinformatics tools, panels of serum-based miRNA, including Results: The expression levels of miR-1, miR-346, and miR-451 were significantly downregulated in GII and GIII compared with GI. However, upregulated expression was observed against miR-200b, miR-320d, NF-κB, and IL-6 in GIII when compared with GI. In GIII, miR-451a ( Conclusion: The selected panel of miRNAs has served as diagnostic biomarkers against HCV-HCC.

Identifiers

PMID42005688
PMCPMC13084151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.