ArticleHealth science reports2026
Systematic Druggable Genome-Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
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Abstract
Background and Aims: Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging-related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable drugs. Methods: We integrated druggable genome data, Results: MR analysis identified five potential druggable genes related to aging: ATP1B3, VKORC1, SLC5A11, HNRNPA1, and SMN2. Phe-MR revealed no significant adverse effects when targeting these genes. Mediation MR identified ten plasma proteins linking these genes to aging, offering mechanistic insights. Drug repurposing analysis supports that cardiac glycosides, Bisacodyl, Olsalazine, and Tegoprazan might be potential therapeutics for aging by inhibiting ATP1B3. Conclusions: Our research indicates that ATP1B3, VKORC1, SLC5A11, HNRNPA1, and SMN2 are potential targets for antiaging therapies. These findings could help prioritize the development of aging-related drugs.
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