ArticleHealth science reports2026
Diagnostic Value of Inflammatory Biomarkers in Bacterial Meningitis: A Cross-Sectional Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Bacterial meningitis (BM) is a potentially life-threatening condition that could rapidly progress to permanent brain damage, neurologic complications, or even death. Diagnostic tools to distinguish between BM and aseptic meningitis (AM) are essential to target the appropriate treatment to patients at great risk and concurrently spare patients with AM from wrongful prescription. The aim was to evaluate the diagnostic utility of cerebrospinal fluid (CSF)-malondialdehyde (MDA), C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels for differentiating BM and AM in all age groups. Methods: This was a 2-year retrospective study involving suspected meningitis cases from the five regions of Northern Ghana. We employed a Real-Time PCR multiplex assay to directly detect Results: Only 90 Conclusion: The MDA and LDH levels were not reliable for distinguishing BM status in this study population; rather, CRP was a stronger biomarker for differentiating BM from AM. Larger prospective studies are required to investigate the role of these biomarkers in BM cases.
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