ArticleHealth science reports2026
Linkage Between miR-218-2 (rs11134527) Genetic Polymorphism and Breast Cancer Risk: A Case-Control Study in the Bangladeshi Women.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: The growth and spread of breast carcinoma are influenced by genetic factors. Diverse forms of cancer have been reported to display multiple subtypes of the Methods: A total of 303 participants (158 breast cancer patients and 145 healthy controls) were enrolled. Clinical and demographic data were collected through structured questionnaires and hospital records. Genotyping of miR-218-2 rs11134527 was performed using the T-ARMS-PCR technique. Statistical analyses were conducted with SPSS v25.0 and MedCalc v19.0.7. The adjusted odds ratio (aOR) using binary logistic regression that controls for age and BMI was employed to investigate the relationship between the targeted SNPs and the risk of breast cancer. Results: Among the patients, invasive ductal carcinoma was the most frequent histological type (49.61%), followed by lobular carcinoma (17.22%). Grade II tumors (63.75%) were predominant. Ultrasound (64.18%) and biopsy (68.66%) were the most common diagnostic tools. Chemotherapy was the principal treatment (62.12%), with cyclophosphamide (69.62%), doxorubicin (53.80%), and paclitaxel (56.33%) as the most prescribed agents. Genotype analysis revealed that individuals carrying the AA genotype had a significantly higher risk of breast cancer than those with GG (additive model 2: OR = 2.48, 95% CI = 1.12-5.48, Conclusion: The
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