Evidence map›Paper›PMID 42005616›Full record

ArticleResuscitation plus2026

Cerebral blood flow autoregulation during prehospital post-resuscitation care.

Elina Heikkilä, Simo Mäkelä, Markus B Skrifvars, Koen Ameloot, Anders Aneman, Annika Nelskylä, Susanne Ångerman, Milla Jousi, Jouni Nurmi

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Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elina HeikkiläEmergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Simo MäkeläFinnish Institute for Health and Welfare, Finland.
Markus B SkrifvarsDepartment of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital and University of Helsinki, Finland.
Koen AmelootDepartment of Cardiology, Ziekenhuis Oost-Limburg Genk, Genk, Belgium.
Anders AnemanIntensive Care Unit, Liverpool Hospital, Sydney, Australia.
Annika NelskyläEmergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Susanne ÅngermanEmergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Milla JousiDepartment of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital and University of Helsinki, Finland.
Jouni NurmiEmergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Successfully resuscitated out-of-hospital cardiac arrest (OHCA) patients often experience cerebral malperfusion, possibly due to impaired autoregulation. Understanding the link between arterial pressure and cerebral blood flow (CBF) is essential for optimising cerebral oxygenation. This study examined early post-resuscitation CBF autoregulation and assessed the feasibility of identifying patient-specific optimal mean arterial pressure (MAPopt) from data obtained during prehospital care. Methods: We performed a post hoc analysis of 12 OHCA patients treated by a physician-staffed helicopter emergency services unit. Frontal lobe regional oxygen saturation (rSO Results: The mean duration of near-infrared spectroscopy monitoring was 47 min. MAPopt was identifiable in eight of 12 patients (66%). Seven patients (58%) showed impaired autoregulation, as mean COx > 0.3. Map and rSO Conclusions: Cerebral autoregulation assessment after OHCA is feasible with physiological data recorded in prehospital setting. Low blood pressure was associated with reduced cerebral oxygenation. Impaired autoregulation was found in most patients. Large inter-individual variation in optimal blood pressure precluded the determination of a common target pressure and emphasises the need for personalised haemodynamic management in the ultra-acute post-resuscitation phase.

Indexed as

Cardiac arrestEmergency medical servicesHelicopter emergency medical servicesPost-resuscitation

Identifiers

PMID42005616
PMCPMC13091529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.