Evidence map›Paper›PMID 42005554›Full record

ArticleAtherosclerosis plus2026

Associations of NMR metabolic biomarkers and arterial calcification: An observational and Mendelian randomization study within the BBMRI metabolomics consortium.

Haojie Lu, Maxime M Bos, Nicolien A van Vliet, Mohsen Ghanbari, Marian Beekman, Luoshiyuan Zuo, Pooja Mandaviya, Dina Vojinovic, Carolina Medina-Gomez, Katerina Trajanoska and 7 more

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Article in Atherosclerosis plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Haojie LuDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Maxime M BosDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Nicolien A van VlietSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Marian BeekmanSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Luoshiyuan ZuoDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Pooja MandaviyaDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Dina VojinovicDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Katerina TrajanoskaDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
P Eline SlagboomSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
BBMRI Metabolomics Consortium
Jeroen van der GrondDepartment of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Diana van HeemstSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Daniel BosDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: The metabolic roles in arterial calcification remain largely unclear. We aimed to elucidate the associations between nuclear magnetic resonance (NMR) metabolic biomarkers with site- and sex-specific arterial calcification as well as their causal nature. Methods: This study included participants from the Rotterdam Study (RS, N = 1062), Leiden Longevity Study (LLS, N = 272), and UK Biobank (UKBB, N = 271,793). In RS and LLS, we applied linear regression (both overall and sex-stratified) to assess the association between NMR metabolic biomarkers and arterial calcification at coronary artery (CAC), aortic arch (AAC), and aortic valve (AVC). Two-sample Mendelian randomization (MR) was employed using genome-wide association study of NMR biomarkers (N = 115,082) and CAC (N = 26,909) to infer their genetic causality. Biomarkers with consistent observational and causal associations were further examined for associations with coronary heart disease (CHD) in UKBB. Results: From multiple-testing correction (P-value < 4.39 × 10 Conclusions: We identified NMR-based metabolic biomarkers, particularly fatty acid ratios, that were significantly and causally associated with CAC burden. GlycA was associated with CAC in males only. Replication in UKBB further underscores their clinical relevance with CHD.

Indexed as

Arterial calcificationCoronary heart diseaseMendelian randomizationNMR metabolic biomarkersObservational associationsSex-stratification

Identifiers

PMID42005554
PMCPMC13091362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.