Evidence map›Paper›PMID 42005471›Full record

ArticleJournal of pharmacy & bioallied sciences

Assessment of Antimicrobial Activity of LL-37 Peptide Against Periapical Pathogens: A Cross-Sectional Study.

Kolasani Balaram, Rahul Tiwari, Heena Dixit Tiwari, PrudviRaj Parimi, Kanwarpreet Singh, Varun Vohra, M C Prashant

Abstract read
In one paragraph

Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kolasani BalaramGeneral Dentist, Aspen Dental, Manitowoc, Wisconsin, USA.
Rahul TiwariDepartment of Oral and Maxillofacial Surgery, RKDF Dental College and Research Centre, Sarvepalli Radhakrishnan University, Bhopal, Madhya Pradesh, India.
Heena Dixit TiwariDepartment of Hospital Administration, Malwanchal University, Indore, Madhya Pradesh, India.
PrudviRaj ParimiDepartment of Conservative Dentistry and Endodontics, Gitam Dental College and Hospital, Vishakhapatnam, Andhra Pradesh, India.
Kanwarpreet SinghDepartment of Conservative Dentistry and Endodontics, Yamuna Institute of Dental Sciences and Research, Yamunanagar, Haryana, India.
Varun VohraConsultant Dental Surgeon, National Dental College and Hospital, Dera Bassi, Punjab, India.
M C PrashantDepartment of Oral and Maxillofacial Surgery, RKDF Dental College and Research Centre Bhopal, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reinfection in the root canal and periradicular area due to the emergence of antibiotic resistance and/or multidrug-resistant strains of mixed colonization of multispecies periapical endodontic is the main reason for endodontic treatment failures. This has imposed a serious public health concern, contributing to decreased clinical efficiency and poor treatment outcomes. To combat these issues, "antimicrobial peptides are considered as potential alternatives and a promising agent" in endodontics. Objective: To evaluate and compare the antimicrobial efficiency of LL-37 peptide against periapical endodontic pathogens ( Methodology: A multispecies biofilm of Results: LL-37 peptides showed statistically significant correlation w.r.t CFUs and antimicrobial activity ( Conclusion: LL-37 peptides were highly effective against periapical endodontic pathogens and hence could be used as a potential therapeutic agent in the future for endodontics.

Indexed as

Antibiofilmantimicrobial peptidesendodontic pathogensLL-37 peptidemultispecies biofilmsreinfectionroot canal

Identifiers

PMID42005471
PMCPMC13086371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.