ArticleFrontiers in nutrition2026
Association between PNI and all-cause mortality in ischemic stroke patients: a large-scale retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aims to explore the correlation between the prognostic nutritional index (PNI) and all-cause mortality in patients diagnosed with ischemic stroke (IS). Methods: A single-center retrospective cohort study was conducted at Dandong Central Hospital, enrolling 1,152 consecutive patients with IS who were discharged from January to December 2024. Multivariate Cox regression models, subgroup analysis, sensitivity analysis, receiver operating characteristic (ROC) curve, and Kaplan-Meier survival analysis were employed to investigate the association between the PNI and all-cause mortality. Results: During a median follow-up period of 14.23 months, a total of 96 (8.3%) patients experienced all-cause mortality. Multivariate Cox regression analysis showed that after adjusting for multiple confounding factors, each 1-unit increase in PNI was associated with an 8.5% reduction in all-cause mortality risk (hazard ratio [HR] = 0.915, 95% confidence interval [CI]: 0.883-0.947, Conclusion: The PNI establishes itself as an independent prognostic biomarker in IS patients, with higher levels correlating with a lower all-cause mortality risk.
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