ArticleThe archives of bone and joint surgery2026
Computer-Assisted Surgery is Associated with Reduced Inflammatory Response in Total Knee Arthroplasty: A Randomized Double-Blinded Control Trial.
Article in The archives of bone and joint surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Total knee arthroplasty (TKA) is a standard treatment for advanced knee osteoarthritis (OA), but intramedullary reaming used in conventional (CON)-TKA may increase surgical trauma, blood loss, and systemic inflammation. Computer-assisted surgery (CAS)-TKA avoids canal entry and may reduce these adverse effects. This study compared postoperative inflammatory markers between CON-TKA and CAS-TKA. Methods: The study was approved by the Institutional Review Board on September 25, 2019 (COA no. 161/61). Participants were recruited from May 2019 to August 2020, and the trial was retrospectively registered with the Thai Clinical Trials Registry on February 24, 2021 (TCTR20210224007). Forty patients with primary knee OA (mean age 67 years) were randomly assigned to CON-TKA or CAS-TKA. Serum inflammatory markers-interleukin-6, C-reactive protein, and erythrocyte sedimentation rate (sIL-6, sCRP, ESR)-were collected at baseline and at 24 h, 72 h, and 2 weeks after surgery. Synovial markers (jIL-6, jCRP) were obtained intraoperatively and from Hemovac drainage at 24 h. Functional outcomes were assessed using the Knee Osteoarthritis Outcome Score (KOOS) at 2 weeks. Results: The sIL-6 and sCRP levels and ESR at 24 h, 72 h, and 2 weeks after surgery were significantly elevated compared with those at baseline. The CAS-TKA group had a significantly lower change in the sIL-6 and ESR at 2 weeks than the CON-TKA group (5.3 ± 2.9 vs 7.9 ± 4.8, P = 0.040, and 35 ± 16 vs 51 ± 22, P = 0.013). Synovial marker levels did not significantly differ between the two groups. Further, there were no significant differences in KOOS at 2 weeks between the two groups. Conclusion: Compared with CON-TKA, CAS-TKA had a lower inflammatory response and a smaller change in sIL-6 and ESR levels at 2 weeks after surgery. However, its functional benefits should be further investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.