Evidence map›Paper›PMID 42005380›Full record

ArticleNeurobiology of stress2026

Early life visceral stress induces auditory brainstem sensitization and cochlear proteomic alterations in a rat model of irritable bowel syndrome.

Li-Yuan Zhang, Xing-Li Li, Yuan-Yuan Jing, Li-Sheng Yu

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Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li-Yuan ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, Beijing, 100044, China.
Xing-Li LiDepartment of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, Beijing, 100044, China.
Yuan-Yuan JingDepartment of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, Beijing, 100044, China.
Li-Sheng YuDepartment of Otorhinolaryngology Head and Neck Surgery, Peking University People's Hospital, Beijing, 100044, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early life stress is increasingly recognized as a critical factor shaping neural development and long-term sensory processing. It is also a well-established driver of visceral dysfunction and central to the pathogenesis of irritable bowel syndrome (IBS). While gastrointestinal and psychological consequences are well documented, its impact on auditory function remains unclear. Here, we employed neonatal colorectal distension in Sprague-Dawley rats to model early life visceral stress and IBS. At 7 weeks, rats exhibited pronounced visceral and somatic hypersensitivity, validated by abdominal withdrawal reflex scores and von Frey testing. Auditory brainstem responses (ABR) revealed markedly shortened wave latencies and increased amplitudes across click and tone stimuli despite normal thresholds, indicating auditory pathway hyperexcitability (

Indexed as

Auditory brainstem responseCochlear proteomicsDevelopmental psychobiologyEarly life stressIrritable bowel syndrome

Identifiers

PMID42005380
PMCPMC13091444

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.