Evidence map›Paper›PMID 42005346›Full record

ArticleInternational journal of pharmaceutics: X2026

Hot-melt extruded ibuprofen ternary solid dispersions using in-line UV-Vis: Impact of an ionizable polymer on thermodynamics and dissolution.

Matheus de Castro, Melissa Almeida, Christian Luebbert, Shadrack Joel Madu, Jatin Khurana, Mark Evans, Matthew Leivers, Gabriel Araujo, Mingzhong Li, Walkiria Schlindwein

Abstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matheus de CastroLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom.
Melissa AlmeidaDepartment of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Christian LuebbertAmofor GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Shadrack Joel MaduLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom.
Jatin KhuranaReckitt Benckiser, Dansom Lane, Hull HU8 7DS, United Kingdom.
Mark EvansReckitt Benckiser, Dansom Lane, Hull HU8 7DS, United Kingdom.
Matthew LeiversReckitt Benckiser, Dansom Lane, Hull HU8 7DS, United Kingdom.
Gabriel AraujoDepartment of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Mingzhong LiLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom.
Walkiria SchlindweinLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amorphous solid dispersions (ASDs) remain a key strategy for enhancing the dissolution of poorly soluble APIs. Building on previous work with binary ibuprofen (IBU) blends, this study investigates the impact of incorporating poly(butyl methacrylate-

Indexed as

Amorphous solid dispersionDissolutionPC-SAFTStabilityThermodynamics

Identifiers

PMID42005346
PMCPMC13091325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.