ArticleFood science & nutrition2026
Coffee Consumption and Risk of Diabetic Angiopathy: Mediating Role of Gut Microbiota Revealed by Mendelian Randomization.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic angiopathy (DA) is a severe complication of diabetes mellitus, contributing significantly to morbidity and mortality. Although traditional mechanisms emphasize hyperglycemia-induced oxidative stress and inflammation, emerging evidence highlights the role of gut microbiota in diabetes and its complications. Coffee consumption, rich in bioactive compounds, has been linked to metabolic health, but its relationship with DA remains unclear due to confounding factors. This study employed Mendelian randomization (MR) to investigate the causal effects of coffee consumption on DA and the mediating role of gut microbiota. Using genetic variants as instrumental variables, we analyzed summary data from large genome-wide association studies on coffee consumption, gut microbiota, and DA. Results indicated a causal association between higher coffee consumption and increased DA risk, with specific gut microbial
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