ArticleCureus2026
Robustness Comparison of the Virtual Bolus Method and Robust Optimization in Postmastectomy Radiation Therapy Using Volumetric Modulated Arc Therapy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background In postmastectomy radiation therapy (PMRT), respiratory motion compromises dose delivery. Quantitative comparisons between virtual bolus (VB) and robust optimization (RO) remained limited, and there is no definitive consensus regarding optimal skin-flash strategies. This study evaluated the relative motion robustness of VB and RO in PMRT and explored the influence of VB thickness and density on dosimetric robustness. Methodology This study included 20 patients with left-sided PMRT planned in RayStation using standard optimization (SO), VB (27 combinations of three planning target volume (PTV) margins, three VB thicknesses, and three densities), and RO (three uncertainty settings). Respiratory motion was simulated by shifting the isocenter by 3-15 mm. Robustness was quantified using changes in chest wall D
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