Evidence map›Paper›PMID 42005227›Full record

ArticleCureus2026

Incidence or Coincidence: Subaortic Membrane, Bicuspid Aortic Valve, and Aortic Root Dilatation in a Patient Presenting With Stroke.

Goitom Weldearegay, Sofia R Khan, Francesca Cali, Asher Gorantla, Suzette Graham-Hill

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Goitom WeldearegayInternal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Sofia R KhanInternal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Francesca CaliInternal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Asher GorantlaCardiology, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Suzette Graham-HillCardiology, Kings County Hospital, Brooklyn, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation and is frequently associated with progressive aortopathy. Subaortic membrane, a discrete form of left ventricular outflow tract (LVOT) obstruction, is uncommon in adults and rarely coexists with BAV outside of complex congenital syndromes. The simultaneous presence of BAV, aortic root dilation, and a subaortic membrane represents an unusual anatomical constellation with important diagnostic and clinical implications. We present the case of a 49-year-old man with no known medical history who developed sudden, painless monocular vision loss and was diagnosed with left central retinal artery occlusion (CRAO). Neurovascular imaging revealed mild carotid atherosclerosis and incidental ascending aortic dilation. Transthoracic echocardiography (TTE) demonstrated a probable BAV, left atrial enlargement, and a suspected subaortic membrane with elevated LVOT gradients. Transesophageal echocardiography confirmed BAV morphology, mild aortic stenosis, and aortic root dilation measuring 4.2 cm, along with severe atherosclerotic plaque in the aortic arch, suggesting an embolic source. This case highlights the importance of comprehensive cardiac evaluation in patients with unexplained embolic events and expands the spectrum of structural abnormalities associated with BAV. Recognition of this rare triad is important for appropriate surveillance, risk stratification, and multidisciplinary management.

Indexed as

aortic root dilationatherosclerotic plaquebicuspid aortic valve diseasecentral retinal artery occlusion (crao)subaortic valvular membrane

Identifiers

PMID42005227
PMCPMC13084908

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.