ArticleCureus2026
Association Between Total Serum Immunoglobulin E Levels and Persistent Pruritus Following Scabies Treatment: An Observational Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundScabies is a common parasitic skin infestation associated with significant immune activation. Elevated total serum immunoglobulin E (IgE) levels have been reported in scabies; however, their association with persistent pruritus following treatment remains unclear.
methodsThis observational analytical study with follow-up assessment included 66 subjects (30 scabies, 36 non-scabies) recruited from Sardjito General Hospital, affiliated hospitals (Sleman Regional General Hospital), and boarding schools in Yogyakarta, Indonesia. Scabies was diagnosed using the 2020 International Alliance for the Control of Scabies (IACS) criteria. Total serum IgE levels were measured once at baseline using electrochemiluminescence immunoassay. Pruritus severity was assessed using the Visual Analogue Scale (VAS) at weeks 0, 2, 4, and 8 following treatment with topical permethrin 5% cream with a repeat application after one week according to standard treatment recommendations. Non-normally distributed data were summarized using median and interquartile range (IQR). Statistical analysis was performed using the Mann-Whitney U test and Spearman correlation.
resultsThe scabies group demonstrated significantly higher total serum IgE levels compared to the non-scabies group (median 570.80 IU/mL (IQR 100.36-5179.00) vs. 36.57 IU/mL (IQR 2.92-193.00); p < 0.001). Baseline total serum IgE levels showed a strong positive correlation with pruritus severity at week eight following treatment (ρ = 0.777; p < 0.001).
conclusionTotal serum IgE levels were significantly higher in patients with scabies and were associated with persistent pruritus after treatment. These findings suggest a possible link between systemic immune activation and ongoing symptoms. However, due to the observational study design, causal inference cannot be made, and the lack of parasitological confirmation of mite eradication should be considered when interpreting these results.
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