ArticleCureus2026
Anterior Horn Cell Disease in Adulthood: Unmasking Spinal Muscular Atrophy Type 4.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal muscular atrophy (SMA) type 4 is a rare, adult-onset motor neuron disorder characterized by slowly progressive proximal weakness with preserved ambulation. Its indolent clinical course and nonspecific early manifestations frequently result in prolonged diagnostic delays. We present the complete diagnostic evaluation of a 33-year-old male patient with a multi-year history of painless, progressive lower extremity weakness. Initial laboratory testing revealed an isolated elevation of creatine kinase (CK) and vitamin D deficiency, with otherwise normal metabolic, endocrine, and inflammatory studies. Persistent CK elevation despite vitamin repletion prompted a neuromuscular referral. Electrodiagnostic testing demonstrated normal nerve conduction studies with electromyographic evidence of widespread chronic active denervation and, critically, normal paraspinal musculature. This pattern strongly supported the localization of the pathology to the anterior horn cells. Subsequent genetic testing confirmed a homozygous deletion of exon 7 in the
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