ArticleMetabolism open2026
COVID-19 and metabolic health: Lessons from a global pandemic.
Article in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has highlighted the critical role of metabolic health in shaping susceptibility to infection, disease severity, therapeutic response, and vaccine-induced immunity. Accumulating clinical and experimental evidence has shown a bidirectional relationship between SARS-CoV-2 infection and metabolic dysfunction, whereby pre-existing cardiometabolic disorders exacerbate clinical outcomes, while COVID-19 itself induces acute and persistent metabolic derangements. This Special Issue explores COVID-19 through an immune-metabolic lens, integrating mechanistic insights, clinical perspectives, therapeutic strategies, and preventive approaches. Its contributions address key pathways linking SARS-CoV-2 to insulin resistance, adipose tissue dysfunction, hepatic inflammation, and immune dysregulation. They also critically evaluate metabolism-oriented pharmacological interventions, including drug repurposing and host-directed therapies, and examine the role of nutrition, lifestyle factors, and metabolic health in modulating disease severity and vaccine-induced humoral responses. Collectively, these works underscore metabolism as a central biological interface in COVID-19 pathophysiology and highlight integrated, host-centered strategies spanning prevention, treatment, and immune resilience. This Special Issue aims to advance understanding at the intersection of infectious disease and metabolism, and to stimulate future research toward improved risk stratification, therapeutic innovation, and long-term public health preparedness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.