Evidence map›Paper›PMID 42005011›Full record

ArticleInternational journal of cardiology. Congenital heart disease2026

Pregnancy in women with vascular Ehlers-Danlos syndrome: a case series from the registry of pregnancy and cardiac disease (ROPAC) III.

P N J Peters, J A van der Zande, S K Prakash, J Harris, E Troost, D Tobler, B J Bouma, J W Roos-Hesselink, ROPAC investigators

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Congenital heart disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

P N J PetersDepartment of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
J A van der ZandeDepartment of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
S K PrakashDepartment of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
J HarrisDepartment of Cardiology, North Shore Private Hospital, St Leonards, Sydney, Australia.
E TroostDepartment of Cardiology, University Hospital Leuven, Leuven, Belgium.
D ToblerDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
B J BoumaDepartment of Cardiology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
J W Roos-HesselinkDepartment of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ROPAC investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vascular Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder associated with high pregnancy-related risks. Current guidelines consider vEDS an mWHO IV high-risk pregnancy, but data are limited and often retrospective. Methods: This prospective case series reports pregnancy outcomes and aortic measurements in six women with confirmed or suspected vEDS enrolled in the ROPAC III registry. Results: No maternal deaths or aortic dissections occurred. One fetal death was reported. Obstetric complications were common, including preterm birth and hemorrhage. Most women delivered via cesarean section. No significant aortic growth was observed during pregnancy. Conclusions: In women diagnosed with vEDS prior to pregnancy, the absence of life-threatening vascular events suggests pregnancy may be safer than previously reported. These findings support more individualized counseling and underscore the need for further prospective studies.

Indexed as

Case seriesPregnancyROPACVascular Ehlers-Danlos syndrome

Identifiers

PMID42005011
PMCPMC13091152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.