Evidence map›Paper›PMID 42004969›Full record

ReviewFrontiers in immunology2026

The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways.

Xin-Yang Bai, Gui-Lin Wang, Yue Zhang, Qian Cheng, Hui-Ning Feng, Linyu Wei, Hai-Yan Sheng, Yaling Yin, Sebastien Roger, Lin-Hua Jiang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xin-Yang BaiDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Gui-Lin WangDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Yue ZhangDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Qian ChengDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Hui-Ning FengDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Linyu WeiDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Hai-Yan ShengDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Yaling YinDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Sebastien RogerINSERM U1327 ISCHEMIA 'Membrane Signalling and Inflammation in Reperfusion Injuries', Faculty of Medicine, University of Tours, Tours, France.
Lin-Hua JiangDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.
Huifang HouDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Medical University, Xinxiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a prevalent neuropsychiatric disorder with high incidence and causing severe disability, representing a clinically unmet challenge and thus demanding more effective therapeutics. Neuroinflammation in the central nervous system (CNS) is a pathological feature of depression and, with increasing recognition, it is also a critical depression-driving mechanism. In the CNS, the P2X7 receptor for extracellular ATP is expressed in microglia and astrocytes, and acts as a key mediator of neuroinflammation. Besides medicinal chemistry efforts in developing novel CNS-penetrable P2X7 antagonists, there is an increasing interest in exploring natural products as medications for CNS conditions including depression. In this mini-review, we discuss the recent progress in examining the therapeutic potential and mechanisms of compounds from natural products, using rodent models of depression, and revealing P2X7-mediated proinflammatory signaling pathways as an important target for their antidepressant actions.

Indexed as

Antidepressive AgentsBiological ProductsDepressionPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Signal TransductionAnimalsHumansNeuroinflammatory DiseasesAntidepressive AgentsBiological ProductsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7antidepressant effectsdepressionnatural productsneuroinflammationP2X7 receptor

Identifiers

PMID42004969
PMCPMC13082957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.