ArticleBiomaterials and biosystems2026
TeSe nanoparticle-integrated exosomes for accelerated diabetic Pressure ulcer healing via NIR-II triggered synergy.
Article in Biomaterials and biosystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic wounds, particularly combined with pressure ulcers, pose significant therapeutic challenges due to their complex pathophysiology. Conventional treatment strategies often fail to adequately address the multifactorial impairment of healing in these conditions. Here, we proposed and investigated a combinatory strategy employing human adipose-derived mesenchymal stem cell-derived exosomes (hADSC-Exos) with near-infrared-II (NIR-II)-responsive selenium telluride (TeSe) nanoparticle-mediated photothermal therapy (PTT). A full-thickness skin defect pressure ulcer model in diabetic mice was established to systematically evaluate different exosome administration regimens (single high-dose vs. multiple low-dose injections) and their combination effect with TeSe nanoparticle and NIR-II irradiation. We find that multiple low-dose subepidermal injections of hADSC-Exos resulted in more pronounced healing compared to a single high-dose strategy. The combination of low-dose exosomes with TeSe+NIR-II PTT markedly enhanced wound closure quality and stimulated hair follicle regeneration within 21 days.
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