ArticleInternational journal of mental health and addiction2025
Efficacy of Continuous Theta Burst Stimulation to the Pre-supplementary Motor Area in Gambling Disorder: a Randomized Double-Blind Controlled Trial.
Article in International journal of mental health and addiction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gambling disorder (GD) is a condition constituting a public health concern due to its impactful detrimental consequences for affected individuals and its very high social costs. Given the lack of FDA-approved treatments, novel non-pharmacological interventions are warranted. In this double-blind randomized controlled trial, we aimed to investigate the effects of continuous Theta Burst Stimulation (cTBS) in patients with GD. Twenty-nine patients with a diagnosis of GD were included and randomly assigned to active or sham condition. In the active condition, participants received 10 sessions of cTBS over pre-SMA bilaterally. Patients were evaluated at baseline and at the end of treatment with the Pathological Gambling version of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS) as primary outcome measure, and with the following secondary measures: Hamilton Anxiety Scale (HAM-A), Hamilton Depression Scale (HAM-D), Gambling Urges Scale (GUS), Barratt Impulsiveness Scale (BIS-11), Sheehan Disability Scale (SDS), Fagerstrom Test for Nicotine Dependence (FTND). A two-way repeated measures ANOVA revealed a significant "group" × "time" interaction for PG-YBOCS and GUS measures. Within group comparisons revealed that PG-YBOCS scores (
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