Evidence map›Paper›PMID 42004895›Full record

ArticleMolecular neurodegeneration advances2026

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline.

Brijendra Singh, Andre F Batista, Emma T Spooner, Brianna R Colletti, Takaomi C Saido, Michael C Carroll, Cynthia A Lemere

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurodegeneration advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brijendra SinghDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Andre F BatistaDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Emma T SpoonerDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Brianna R CollettiDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Takaomi C SaidoRIKEN Center for Brain Science, Wako, Saitama, Japan.
Michael C CarrollProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cynthia A LemereDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

Funding

Evolution of autoreactive GC and epitope spreading in lupusR01AR074105 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Michael Craig Carroll · 2018 to 2026
$4.2M
Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in ADRF1AG060057 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEMERE, CYNTHIA A · 2018 to 2018
$3.4M
FDC regulation of self-reactive B cellsR01AI130307 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CARROLL, MICHAEL CRAIG · 2018 to 2022
$2.7M
Understanding and Mitigating Vascular Side-Effects Associated with Anti-Amyloid ImmunotherapyR01NS136122 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI CYNTHIA A LEMERE · 2024 to 2026
$2.5M
Generation of a Complement C3 Conditional Knockout MouseR21AG044713 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEMERE, CYNTHIA A · 2013 to 2014
$475k
NIAID NIH HHS R01 AI130307NIAMS NIH HHS R01 AR074105NIA NIH HHS R21 AG044713NIA NIH HHS RF1 AG060057NINDS NIH HHS R01 NS136122
6 · The paper itself

Abstract

Background: We previously reported that germline complement Methods: Results: Serum C3 levels were reduced by ~ 85% 30-days post-TAM treatment and ~ 70% at the end of the study. TAM-treated Conclusion: Global complement C3 lowering in adult

Indexed as

Amyloid-βAPP-KI miceCognitionComplement C3Hippocampal synapsesNeuroinflammation

Identifiers

PMID42004895
PMCPMC13089770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.