ArticleMetabolism open2026
Comparative effects of regular, bloomed or white chocolate on cardiovascular and antioxidant markers in healthy adults.
Article in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, highlighting the need for effective dietary strategies to mitigate risk. Cocoa-rich dark chocolate contains bioactive compounds with reported cardioprotective effects; however, evidence regarding the impact of fat-bloomed chocolate in humans is limited. This study evaluated the effects of 15-day consumption of isocaloric portions (316 kcal/day; ∼50 g) of regular dark chocolate (70% cocoa), bloomed dark chocolate (70% cocoa), and white chocolate (0% cocoa) on cardiovascular and antioxidant markers in healthy adults. Methods: Thirty-six participants (27 females, 9 males) completed the intervention. Outcome measures included blood pressure, skin blood flow, lipid profile, fasting glucose, inflammatory markers, and total antioxidant capacity. The study also assessed whether fat blooming alters the functional properties of dark chocolate. Results: Neither regular nor bloomed dark chocolate significantly affected blood pressure or skin blood flow. In contrast, white chocolate significantly reduced skin blood flow (P = 0.015). Both dark chocolate groups demonstrated non-significant changes toward lower fasting glucose (P = 0.090) and higher high-density lipoprotein (HDL) cholesterol (P = 0.088), changes not observed in the white chocolate group. Total antioxidant capacity increased significantly following both dark chocolate interventions (P < 0.05), with no change in the white chocolate group. Conclusion: Bloomed dark chocolate retained comparable antioxidant and cardiometabolic effects to regular dark chocolate. These findings suggest that fat blooming does not diminish the functional properties of dark chocolate. Larger, longer-term studies are needed to confirm these findings and inform recommendations for chocolate consumption in CVD prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.