Evidence map›Paper›PMID 42004764›Full record

ArticleAmerican journal of ophthalmology case reports2026

Intravitreal Bevacizumab plus Methotrexate for iris and ciliary body metastasis from lung cancer.

Thaís Marino de Azeredo Bastos, Igor Neves Coelho, Leticia Audi, Fernando Chahud, Marco Folgosa, Zelia Maria Correa, Rodrigo Jorge

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thaís Marino de Azeredo BastosDepartments of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Igor Neves CoelhoDepartments of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Leticia AudiDepartments of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Fernando ChahudDepartments of Pathology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Marco FolgosaDepartments of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Zelia Maria CorreaBascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Rodrigo JorgeDepartments of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe a case of iris and ciliary body metastasis from lung adenocarcinoma responding to intravitreal bevacizumab and methotrexate. Observations: A 66-year-old man presented with an amelanotic vascular lesion of the iris and ciliary body (7 × 4 mm, 4 mm thick). Fine-needle aspiration biopsy confirmed lung adenocarcinoma. After intravitreal bevacizumab and methotrexate, the tumor showed marked regression within 2 months. Conclusions: Intravitreal bevacizumab combined with methotrexate may represent a minimally invasive alternative to radiation therapy for ocular metastases.

Indexed as

BevacizumabIris neoplasmsMethotrexateNeoplasm metastasis

Identifiers

PMID42004764
PMCPMC13089013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.