Evidence map›Paper›PMID 42004758›Full record

ReviewJSES reviews, reports, and techniques2026

Biologic augmentation in rotator cuff repair: current evidence and future directions.

Antoine Saber, Anthony El Dada, Carine Mardelli, Ryan Akl, Wendy Ghanem, Ramzi Moucharafieh, Mohamad Badra, Hady Ezzeddine

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JSES reviews, reports, and techniques, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antoine SaberDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Anthony El DadaDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Carine MardelliDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Ryan AklDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Wendy GhanemDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Ramzi MoucharafiehDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Mohamad BadraDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Hady EzzeddineDepartment of Orthopedics and Traumatology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite surgical advancements, high failure rates of rotator cuff repairs (RCRs) remain a significant concern, with success rates varying from 16% to 94%. This paper reviews current evidence on biologic augmentation strategies, including platelet-rich plasma, mesenchymal stem cells, and biologic scaffolds, that improve healing and reduce retear rates. Current research on biologic augmentation presents mixed results. While preclinical and clinical studies show improved structural healing and functional scores, a lack of standardized protocols for application, concentration, and surgical technique leads to heterogeneity in outcomes. The review also touches on other emerging modalities like gene therapy and amniotic membrane-derived products. Biologic augmentation holds great promise for optimizing rotator cuff repairs; however, to achieve clinical effectiveness and widespread adoption, future research must focus on large-scale human trials to establish standardized protocols that would most benefit patients.

Indexed as

Amniotic membrane derived productsBiologic patchesGene therapyPlatelet-rich plasmaRotator cuffScaffoldsStem cells

Identifiers

PMID42004758
PMCPMC13084407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.